Garments and textiles are ubiquitous in our everyday lives. Across textile production, usage, maintenance, and disposal, microplastic fibers (MPFs) seep into environmental compartments (soil, water, air, etc.), endangering ecological systems downstream. Direct use of clothing and exposure to the plastics in its construction pose a significant threat to human health, inhalation being a primary route. In a collaboration funded by the National Cotton Foundation, with expertise in Environmental Health, Civil Engineering, Environmental Epidemiology, and Biology, researchers are characterizing and comparing airborne decomposition of MPFs in synthetic and natural fabrics with a focus on understanding the potential for human inhalational exposure. Investigating the relationship between fabric composition and public health can inform exposure-reduction measures, as well as help to ensure ecosystem protections and preservation.