The Mid-South Mississippi Delta has the potential to become a center of agricultural diversity, productivity, and prosperity in the U.S. Our work is providing strategic guidance on critical opportunities to revitalize the regional agricultural economy and ecosystem. The project includes partners at The University of Arkansas-Pine Bluff, Alcorn State University, Rust College, and Jackson State University to engage stakeholders across the region, including groups in distressed communities. Our work is aimed at informing public policy, business development, regional investment, and research, education, and outreach efforts to support these opportunities and catalyze job creation and long-term economic growth.